Targetome Analysis Revealed Involvement of MiR-126 in
Neurotrophin Signaling Pathway: A Possible Role in
Prevention of Glioma Development
The first two authors equally contributed to this article.
For the first time, we used molecular signaling pathway enrichment analysis to determine possible involvement of miR-126 and IRS-1 in neurotrophin pathway.
Materials and Methods
In this prospective study, validated and predicted targets (targetome) of miR-126 were collected
following searching miRtarbase (
MiR-126 exerts a variety of functions in cancer pathogenesis via suppression of expression of target gene
Taken together, we concluded that miR-126 enhances the formation of glioma cancer stem cell probably via down regulation of IRS-1 in neurotrophin signaling pathway.