Protection of Renal Tubular Cells by Antioxidants: Current Knowledge and New Trends

(Pages: 568-571)
Azar Baradaran, Ph.D, 1Hamid Nasri, M.D, 2Mahmoud Rafieian-Kopaei, Ph.D, 3,*
Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Address: Medical Plants Research Center Shahrekord University of Medical Sciences Sharekord Iran Email:rafieian@yahoo.com
Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Baradaran Azar, Nasri Hamid, Rafieian-Kopaei Mahmoud. Protection of Renal Tubular Cells by Antioxidants: Current Knowledge and New Trends. Cell J. 2015; 16(4): 568-571.

Abstract

Acute renal damage mainly develops following toxic or ischemic insults and is defined as acute. These damages have largely been attributed to oxidative stress. Recently much attention has been directed toward decreased renal tubular cell regeneration during tubular cell injury. Antioxidants have recently been the focus of researchers and scientists for prevention and treatment of various oxidative stress-related conditions, including renal toxicities. Although free radicals are known to contribute in kidney injury and abundant researches, particularly laboratory trials, have shown the beneficial effects of antioxidants against these complications, long term clinical trials do not uniformly confirm this matter, especially for single antioxidant consumption such as vitamin C. The aim of this paper is to discuss the possible explanation of this matter.