The Potential Roles of Actin in The Nucleus

(Pages: 7-14)
Khadijeh Falahzadeh, M.Sc, 1,2Amir Banaei-Esfahani, M.Sc, 3Maryam Shahhoseini, Ph.D, 1,*
Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University (TMU), Tehran, Iran
Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University (TMU), Tehran, Iran
Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
*Corresponding Address: P.O.Box: 16635-148 Department of Genetics at Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran Email:m.shahhoseini@royaninstitute.org
Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Falahzadeh Khadijeh, Banaei-Esfahani Amir, Shahhoseini Maryam. The Potential Roles of Actin in The Nucleus. Cell J. 2015; 17(1): 7-14.

Abstract

Over the past few decades, actin’s presence in the nucleus has been demonstrated. Actin is a key protein necessary for different nuclear processes. Although actin is well known for its functional role in dynamic behavior of the cytoskeleton, emerging studies are now highlighting new roles for actin. At the present time there is no doubt about the presence of actin in the nucleus. A number of studies have uncovered the functional involvement of actin in nuclear processes. Actin as one of the nuclear components has its own structured and functional rules, such as nuclear matrix association, chromatin remodeling, transcription by RNA polymerases I, II, III and mRNA processing. In this historical review, we attempt to provide an overview of our current understanding of the functions of actin in the nucleus.