The Study of rs693 and rs515135 in APOB in People with Familial
APOB-related familial hypercholesterolemia (FH) is the most common hereditary hyperchlosterolemia with
an autosomal dominant pattern. A number of
Materials and Methods
In this case-control study, rs693 (in exon 26 of
This study was analyzed by odds-ratio (OR) and its 95% confidence interval (CI) to examine the association of the two SNPs with familial hypercholostermia susceptibility. Statistical analysis showed that both SNPs were in Hardy- Weinberg equilibrium.
We found no significant relationship between rs515135 and familiar hypercholesterolemia. However, there was a significant association between the C allele of rs693 and high familial cholesterol levels. Furthermore, it seems the dominant model of T allele occurrence has a protective role in emergence of disease.