The Effect of Camphor on Sex Hormones Levels in Rats

(Pages: 231-234)
Sima Shahabi, M.Sc, 1Seyed Gholam Ali Jorsaraei, Ph. D., 2,*Ali Akbar Moghadamnia, Ph.D, 1,3Effat Barghi, Ph.D, 3Ebrahim Zabihi, Ph.D, 1Masoumeh Golsorkhtabar Amiri, B.Sc., 2Ghorban Maliji, Ph.D, 1Alieh Sohan Faraji, M.Sc, 4Maryam Abdi Boora, M.Sc, 1Neda Ghazinejad, B.Sc, 1Hajar Shamsai, B.SC, 1
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran
Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran
Department of Anatomy, Babol University of Medical Sciences, Babol, Iran
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran
Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran
Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran
Department of Anatomy, Babol University of Medical Sciences, Babol, Iran
*Corresponding Addresses: P.O. Box: 47176-47745 Fatemeh-Zahra Fertility and Infertility Reproductive Health Research Center Babol University of Medical Sciences Babol Iran Email:alijorsara@yahoo.com
Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Shahabi Sima, Jorsaraei Seyed Gholam Ali, Akbar Moghadamnia Ali, Barghi Effat, Zabihi Ebrahim, Golsorkhtabar Amiri Masoumeh, Maliji Ghorban, Sohan Faraji Alieh, Abdi Boora Maryam, Ghazinejad Neda, Shamsai Hajar. The Effect of Camphor on Sex Hormones Levels in Rats. Cell J. 2014; 16(2): 231-234.

Abstract

In some traditional therapies, it has been claimed that camphor (a crystalline ketone obtained from cinnamomum camphora) would be a suppressor of sexual behaviors and sex hormones. This study evaluated the effects of camphor on sex hormones, like luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone. In this experimental study, 56 male rats were divided into 5 groups, including control (n=12), sham (n=11) and three treatment groups (n=11) in three different doses. The sham groups received daily intra peritoneal (IP) injections of the vehicle (ethanol 10%) for 30 days. Three treatment groups received different daily IP injections of the camphor (1, 2 and 5 mg/Kg) for 30 days and the control groups didn’t received anything. Serums were used for assaying LH, FSH and testosterone. The level of LH significantly increased in all doses of camphor among the treatment groups as compared to the control (p<0.05), but camphor in doses 2 and 5 mg/Kg significantly reduced the FSH level as compared to control group (p<0.05). No significant changes were seen in testosterone levels. Camphor increased level of LH, decreased level of FSH, whereas it failed to change level of testosterone. The claim of inhibitory effect of camphor on sexual activity could not be confirmed by this study. More investigations in this field are suggested.