In Vitro and In Vivo Comparison of Different Types of Rabbit
Mesenchymal Stem Cells for Cartilage Repair
Khalilifar MA, Baghaban Eslaminejad MR, Ghasemzadeh M, Hosseini S, Baharvand H. In vitro and in vivo comparison of different types of rabbit mesenchymal stem cells for cartilage repair. Cell J. 2019; 21(2): 150-160. doi: 10.22074/cellj.2019.6149.
Systematic studies indicate a growing number of clinical studies that use mesenchymal stem cells (MSCs) for the treatment of cartilage lesions. The current experimental and preclinical study aims to comparatively evaluate the potential of MSCs from a variety of tissues for the treatment of cartilage defect in rabbit’s knee which has not previously been reported.
Materials and Methods
In this experimental study, MSCs isolated from bone marrow (BMMSCs), adipose (AMSCs), and ears
(EMSCs) of rabbits and expanded under
Based on our comparative
It seems that the ear contains MSCs that promote cartilage regeneration as much as the conventional MSCs from the bone marrow. Considering a high proliferation rate and easy harvesting of MSCs of the ear, this finding could be of value for the regenerative medicine.