CD44 Gene rs8193 C Allele Is Significantly Enriched in
Gastric Cancer Patients
Mokhtarian R, Tabatabaeian H, Saadatmand P, Azadeh M, Balmeh N, Yakhchali B, Ghaedi K. CD44 gene rs8193 C allele is significantly enriched in gastric cancer patients. Cell J. 2020; 21(4): 451-458. doi: 10.22074/cellj.2020.6389.
Gastric cancer is a multifactorial disease. In addition to environmental factors, many genes are involved in
this malignancy. One of the genes associated with gastric cancer is
Materials and Methods
In this cross-sectional case-control study, rs8193 polymorphism was genotyped by allele specific primer polymerase chain reaction (ASP-PCR) technique. The obtained data were statistically analyzed. To find the potential mechanism of action, rs8193 was bioinformatically investigated.
rs8193 C allele played a risk factor role for gastric cancer. Patients carrying this allele were more susceptible to have gastric cancer, with lymph node spread. On the other hand, rs8193 T allele, a protective factor, was associated with a higher chance of accumulation in the lower stages of cancer. C allele might impose its effect via destabilizing CD44 and miR-570 interaction.
rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population.