Effect of Plasma-Derived Exosomes of Refractory/Relapsed or
Responsive Patients with Diffuse Large B-Cell Lymphoma on
Natural Killer Cells Functions
Zare N, Haghjooy Javanmard Sh, Mehrzad V, Eskandari N, Andalib AR. Effect of plasma-derived exosomes of refractory/relapsed or responsive patients with diffuse large B-cell lymphoma on natural killer cells functions. Cell J. 2020; 22(1): 40-54. doi: 10.22074/cellj.2020.6550.
The purpose of this study was to investigate effect of plasma-derived exosomes of refractory/relapsed or responsive diffuse large B-cell lymphoma (DLBCL) patients on natural killer (NK) cell functions.
Materials and Methods
In this cross-sectional and experimental study, NK cells were purified from responsive patients
(n=10) or refractory/relapsed patients (n=12) and healthy donors (n=12). NK cells were treated with plasma-derived
exosomes of responsive or refractory/relapsed patients. We examined the expression levels of
We observed an increased level of
Our findings demonstrated adverse effect of plasma-derived exosomes of DLBCL patients on some functions of NK cell. It was also determined that low NK cell count might be associated with impaired response to R-CHOP and an increased recurrence risk of cancer.