hsa-miR-423 rs6505162 Is Associated with The Increased Risk of Breast Cancer in Isfahan Central Province of Iran (Pages: 110-116)


Nadia Pourmoshir , Gholamreza Motalleb *, Sadeq Vallian *,

Objective

13 million cancer deaths and 21.7 million new cancer cases are expected in the world by 2030. Breast cancer is considered as the main cause of cancer mortality in the women aged 20 to 59 years. MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level and are highly expressed in malignancies including breast cancer. The role of miRNAs in the pathogenesis of breast cancer is not fully understood. In the present study, for the first time, the impact of hsa-miR-423 rs6505162 on breast cancer risk was investigated in the Iranian population.

MaterialsAndMethods

The present case control study was conducted on 153 clinicopathological confirmed breast cancer patients and 153 sex-matched healthy women with no history of any types of cancer and not related to the patients. 153 patients with pathologically confirmed breast cancer and 153 controls were genotyped and the association of clinical characteristics of the patients and hsa-miR-423 rs6505162 genotypes was analyzed.

Results

The findings indicated that the CC genotype of hsa-miR-423 rs6505162 was associated with the increased risk of breast cancer [Odds ratio (OR) = 2.37, 95% confidence interval (CI) = 1.29-4.35, and P= 0.0023, CC vs AA].

Conclusion

The data suggested that hsa-miR-423 rs6505162 could be considered as a novel risk factor in breast cancer pathogenesis in the Iranian population.