MicroRNA and Hemophilia-A Disease: Bioinformatics Prediction
and Experimental Analysis
Hemophilia-A is a common genetic abnormality resulted from decreased or lack of factor VIII (FVIII) pro-coagulant
protein function caused by mutations in the
Materials and Methods
In this experimental study that approved by Research Assistant, University of Isfahan, bioinformatics
tools have been utilized to seek the novel microRNAs inserted within human
We are unable to confirm existence of the considered mature microRNAs in the transfected cells.
We hope that through changing experimental conditions, designing new primers or altering cell lines as well as the expression of vectors, exogenous and endogenous expressions of the predicted miRNA will be confirmed.