Neuroprotective Effects of Isoquercetin: An In Vitro and In Vivo Study
Alzheimer’s disease (AD) is considered a neurodegenerative disease that affects the cognitive function of
elderly individuals. In this study, we aimed to analyze the neuroprotective potential of isoquercetin against the
Materials and Methods
The experimental study was performed on PC12 cells treated with lipopolysaccharide (LPS).
Reactive oxygen species (ROS), antioxidant parameters, and pro-inflammatory cytokines were measured. In an
The non-toxic effect on PC12 cells was shown by isoquercetin. Isoquercetin significantly reduced the
production of nitrate and ROS, along with the altered levels of antioxidants. Isoquercetin significantly (P<0.001)
down-regulated proinflammatory cytokines in PC12 cells treated with LPS. In the
Based on the results, we may infer that, through antioxidant and anti-inflammatory systems, isoquercetin prevented neurochemical and neurobehavioral modifications against the model of colchicine-induced AD rats.