Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium

(Pages: 313-318)
Ali Reza Soltanian, Ph.D., 1,2Bistoon Hosseini, Ph.D., 3Hossein Mahjub, Ph.D., 1,4Fatemeh Bahreini, Ph.D., 5Nazemalhosseini Mojarad Ehsan, Ph.D., 6Mohammad Ebrahim Ghaffari, M.Sc., 1,*
Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Kermanshah Province Electricity Distribution Company, Kermanshah, Iran
Research Center for Health Center, Hamadan University of Medical Sciences, Hamadan, Iran
Department of Molecular Medicine and Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Gastrointestinal (GI) Cancer Department, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Kermanshah Province Electricity Distribution Company, Kermanshah, Iran
Research Center for Health Center, Hamadan University of Medical Sciences, Hamadan, Iran
Department of Molecular Medicine and Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Gastrointestinal (GI) Cancer Department, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Address: P.O.Box: 6517838736 Department of Biostatistics School of Public Health Hamadan University of Medical Sciences Hamadan Iran Email:m.gh19@yahoo.com
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Soltanian Ali Reza, Hosseini Bistoon, Mahjub Hossein, Bahreini Fatemeh, Ehsan Nazemalhosseini Mojarad, Ghaffari Mohammad Ebrahim. Association between rs11614913 Polymorphism of The MiR-196-a2 Gene and Colorectal Cancer in The Presence of Departure from Hardy-Weinberg Equilibrium . Cell J. 2021; 23(3): 313-318.

Abstract

Objective

Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the miR-196-a2 gene and CRC.

Materials and Methods

In this case-control study, we assessed association of the rs11614913 polymorphism in 194 patients with CRC (case) and 286 healthy individuals (control). The expectation-maximization (EM) algorithm method was used to adjust deviation from Hardy-Weinberg equilibrium (HWE).

Results

There was no significant difference between genotypic frequencies of rs11614913 polymorphism in the control and case groups. Genotypic frequencies differed in the adjusted and unadjusted deviations from the HWE. Analysis of unadjusted and adjusted independent variables showed that age, sex, alcohol consumption, and drug use were statistically significant.

Conclusion

Our findings showed that rs11614913 polymorphism was not associated with CRC risk. Deviation from HWE affected the results. It is recommended to perform further studies to establish HWE. Ignoring the equilibrium can cause in consistencies in the results of studies.