Positive Association of Matrix Proteins Alteration with TAZ and The
Progression of High-Grade Bladder Cancer
Bladder cancer is the 9th cause of human urologic malignancy and the 13th of death worldwide.
Increased collagen cross-linking,
Materials and Methods
In this case-control study, real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemical analysis were performed to evaluate the activation of the TAZ pathway in patients with bladder cancer (n=40) and healthy individuals (n=20). The ELISA method was also conducted to measure the serum concentrations of TGF-β1. Masson’s trichrome staining was carried out to histologically evaluate the density of type 1 collagen.
Our findings that the expression levels of
According to our findings, it seems the alterations in the expression of type I collagen and