Possible Male Reproduction Complications after Coronavirus Pandemic

(Pages: 382-388)
Maryam Hezavehei, Ph.D, 1Bahare Shokoohian, M.Sc, 2Mohammad Hossein Nasr-Esfahani, Ph.D, 3Anastasia Shpichka, Ph.D., 4Peter Timashev, Ph.D., 4Abdolhossein Shahverdi, Ph.D., 1,*Massoud Vosough, M.D., Ph.D., 2,*
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
*Corresponding Addresses: P.O.Box: 16635-148 Department of Embryology Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine ACECR Tehran Iran P.O.Box: 16635-148 Department of Regenerative Medicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology ACECR Tehran Iran Emails:shahverdi@royaninstotute.org,masvos@royaninstitute.org
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Hezavehei Maryam, Shokoohian Bahare, Nasr-Esfahani Mohammad Hossein, Shpichka Anastasia, Timashev Peter, Shahverdi Abdolhossein, Vosough Massoud. Possible Male Reproduction Complications after Coronavirus Pandemic. Cell J. 2021; 23(4): 382-388.

Abstract

Coronavirus disease 2019 (COVID-19), as a severe respiratory disease, affects various tissues and organs. The specific SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), is highly expressed in male gonads. Thus, male reproductive tissues could be a potential target for virus colonization. We performed a comprehensive search in PubMed and Google Scholar to retrieve relevant articles published till 15 April 2021. The keywords used were: male fertility, male reproductive health, semen parameters, sex hormones, SARS-CoV-2, and COVID-19. Validated evidence about the adverse effects of the SARS-CoV-2 infection on the male reproductive system is limited and few studies have reported semen analysis results or presence of viral RNA in semen samples of infected men. Nevertheless, alterations in reproductive hormones such as decreased level of testosterone (T) with raised luteinizing hormone (LH) have been reported in some patients. Although the impact of SARS-CoV-2 infection on the male reproduction health remains unclear, evidence suggests that male gonads may be potentially vulnerable to SARS-CoV-2 infection. In this article, we discussed the possible impacts of COVID-19 on male gonads, sex hormones, and semen quality and suggested preventive solutions.