The Relationship between Salivary Beta-2 Microglobulin and Uremia Intensity in Men with Chronic Renal Failure

(Pages: 276-281)
Mohammad Vahedi, D.D.S., 1Hossein Malekzadeh, D.D.S., 1,2,*Habib Haybar, M.D., 3Ali Reza Soltanian, Ph.D., 4Shermin Abdollahzadeh, D.D.S., 1Hojjat Yoosefi, D.D.S., 5Masoud Seyedian, M.D., 3Leila Yazdanpanah, M.D., 3Abrotan Saeid, M.D., 3Maryam Shabanpour Fooladi, M.D., 6Marziyeh Ghasemi, M.D., 3
1. Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
2. Department of Oral Medicine, School of Dentistry, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
3. Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
4. Department of Biostatistics and Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
5. Department of Periodontics, School of Dentistry, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
6. Department of Internal Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
1. Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
2. Department of Oral Medicine, School of Dentistry, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
3. Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
4. Department of Biostatistics and Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
5. Department of Periodontics, School of Dentistry, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
6. Department of Internal Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran
* Corresponding Address: P.O.Box: 61357-33118 Department of Oral Medicine Dental Research Center School of Dentistry Hamadan University of Medical Sciences HamadanIran Email:dr_ho_mal@yahoo.com
Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Vahedi Mohammad, Malekzadeh Hossein, Haybar Habib, Soltanian Ali Reza, Abdollahzadeh Shermin, Yoosefi Hojjat, Seyedian Masoud, Yazdanpanah Leila, Saeid Abrotan, Shabanpour Fooladi Maryam, Ghasemi Marziyeh. The Relationship between Salivary Beta-2 Microglobulin and Uremia Intensity in Men with Chronic Renal Failure. Cell J. 2013; 14(4): 276-281.

Abstract

Objective:

This study defines the relationship between salivary beta-2 microglobulin (β2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF).

Materials and Methods:

In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine β2-M, blood urea nitrogen (BUN) and creatinine (Cr) levels.

Results:

There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and β2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and β2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary β2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation between serum Cr and salivary β2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group.

Conclusion:

The results of the study indicated that salivary β2-M cannot be used as a noninvasive indicator to detect the severity of renal failure.